Scientist III/IV, DMPK
Job Category:Preclinical Development
Who We Are
Dart NeuroScience LLC (DNS) is a privately held company with offices in San Diego, CA.
DNS is a company discovering new technologies and developing new therapies to help maintain cognitive vitality throughout life. DNS's mission is to become the leading specialized pharmaceutical company for memory disorders by focusing on the discovery and development of innovative drugs with new mechanisms of action. These discoveries are firmly based in a careful examination of the genes involved in the reorganization of synaptic connections in the brain, a cellular/molecular process which underlies both implicit (motor skills) and explicit (facts and events) forms of memory.
Our unique company culture engages employees by promoting thought-provoking investigation and targeted research opportunities. Our collegial environment also recognizes the value of stimulating cross-functional communication and collaboration as catalysts in generating the creative spark that inspires novel approaches and produces ground-breaking results. We want to attract, retain, and reward the top talent in our field. If you are looking for a productive, meaningful career path in the area of neuroscience, we would like to hear from you!
Dart NeuroScience LLC is seeking an experienced DMPK scientist to conduct, lead and manage in vitro ADME studies supporting the identification and development of clinical candidates. The position will involve the conduct of a variety of in vitro ADME experiments including microsomal and hepatocyte stability, enzyme kinetic assays, Cytochrome P450 reaction phenotyping and inhibition assays, and strategies to detect non-Cytochrome P450-mediated pathways. A thorough understanding of the theoretical and technical aspects of drug metabolizing enzymes and applications to in vitro drug-drug interaction studies is required. Knowledge and experience with HPLC and mass spectrometry is required. The successful candidate must have solid technical skills and the ability to supervise and mentor others in the group. Strong knowledge of FDA guidance documents and GLP practices a plus. This position requires the successful candidate to generate, analyze results and to provide oral and written presentations of the data.
• PhD in chemistry, biochemistry, pharmacology, toxicology or related field with 7+ years of experience.
• Extensive knowledge of DMPK and experience in applying these concepts to problem solving in support of drug discovery and development
• Ability to design, validate and conduct new DMPK assays.
• Good organization, record keeping and communication skills
• Ability to work independently and within a team environment.
DNS offers competitive salaries and a great benefits package including paid holidays, incentive bonuses, healthcare, vision, dental, long-term disability, life insurance, flexible spending, and a 401(k) retirement savings plan. Click here to learn more.
Dart NeuroScience is an Equal Opportunity Employer/Minorities/Women/Disability/Veterans.