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Current Opportunities

Principal Investigator - Toronto, Ontario

Position: Principal Investigator
Site: MaRS Centre, Toronto
Department: Computational Biology
Reports To: Director, Computational Biology
Salary: Commensurate with level of experience
Hours: 35 hours/week
Status: Full-time, Permanent

The Ontario Institute for Cancer Research (OICR) is seeking a Principal Investigator (PI) in Computational Biology to undertake world-class computational research. We seek to strengthen and complement our existing expertise in genomics and cancer genomics, machine-learning, statistical genetics, analysis of next-generation sequencing, knowledge-bases and pathway/network analysis. We welcome applications from computational biologists of all types, but a career focus on cancer research is critical going forward.

The PI will be expected to mentor trainees, and to build collaborations both within and outside the OICR community. In addition to base funds provided by the Institute to support the PI's salary and personnel, the PI is expected to raise additional research funds from external competitive granting agencies. The OICR will assist the PI in obtaining faculty appointments at the University of Toronto or another affiliated academic institution.

OICR’s Computational Biology Program is the home of the ICGC Data Coordination Centre, leads analysis for two ICGC projects (PanCuRx and CPC-GENE), the Ontario Health Study and numerous other large-scale studies. It is the home of multiple international projects (e.g. Pan-cancer Analysis of Whole Genomes, Reactome, ICGC-TCGA DREAM Somatic Mutation Calling Challenge) and provides a robust intellectual environment for computational biology. A ~10,000-core institutional cluster is available to support analysis by the Program.

OICR is a multi-disciplinary, team-science-driven translational research institute. It has research programs in Diagnostic Development, Drug Discovery, Genomics, Imaging and Informatics. These support major national and international initiatives, including a multi-side targeted somatic sequencing study (OCTANE) and the International Cancer Genome Consortium (ICGC). Please visit https://oicr.on.ca/research-portfolio/ for details on our research portfolio.

• An MD or PhD with a proven track record in computational biology, bioinformatics, or biostatistics;
• For new PIs, a record of independent research and either first-author or senior-authored peer reviewed publications or the publication of software, databases or other significant community resources;
• For senior and intermediate-level PIs, international recognition and a strong publication record of relevance, proven leadership and management experience including the building of strong research teams, as well as a strong record of grant-funding and mentorship;
• Excellent communication and presentation skills.

Please attach the following to your application:
• A covering letter, including the names of 3 potential referees;
• A complete academic CV in PDF format;
• A 2-4 page proposed research document, including a section highlighting relevance of the proposed studies to cancer.


This job posting is part of an ongoing recruitment initiative. Resumes will be reviewed on a continuous basis.


OICR is an innovative cancer research institute located in the MaRS Centre in the Discovery District in downtown Toronto. OICR is addressing significant challenges in cancer research with multi-disciplinary, multi-institutional teams. New discoveries to prevent, detect and treat cancer will be moved from the bench to practical applications in patients. The OICR team is growing quickly. We are innovative, dedicated professionals who bring expertise to each of our roles. We are looking for individuals interested in being part of a culture of excellence that will result in Ontario being recognized internationally as a leading jurisdiction for cancer research.

Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Economic Development, Job Creation and Trade.

For more information about OICR, please visit the website at www.oicr.on.ca.

OICR is an inclusive employer dedicated to building a diverse workforce. We encourage applications from all qualified candidates and will accommodate applicants’ needs throughout all stages of the recruitment and selection process. Please advise the Recruiter to ensure your accessibility needs are accommodated throughout this process. Information received relating to accommodation will be addressed confidentially.

The Ontario Institute for Cancer Research thanks all applicants. However, only those under consideration will be contacted.

Resume Format: If you elect to apply, you will need a text or HTML version of your resume so that you can cut and paste it into the application box provided. Before you submit the completed application, you will be asked to attach one or two files to your application. Please attach your resume as a .doc or pdf file.