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Current Opportunities

Postdoctoral Fellow, Computational Chemistry and Chemoinformatics - Toronto, Ontario

Position:  Postdoctoral Fellow, Computational Chemistry and Chemoinformatics
Site:   MaRS Centre, Toronto
Department:  Drug Discovery Program
Reports To:  Scientific Advisor and Group Leader
Salary:  Commensurate with level of experience
Hours: 35 hours/week
Status:  Full-time, Temporary (Two-years)

The Ontario Institute for Cancer Research (OICR) is seeking a post-doctoral scientist with expertise in Computational Chemistry and Chemoinformatics to join the Drug Discovery Program.  Based in Toronto, you will be a part of a dedicated team of scientists to identify and optimize new anti-cancer drug candidates using a wide variety of computational approaches. As a member of the Drug Discovery Program, you will have a chance to use the state-of-the-art OICR hardware facilities (that includes a 8,000-core SGE HPC Cluster with 6 PB data storage) and all major software tools required for Computational Drug Discovery. You will closely collaborate with a team of scientists with a broad Pharma and Biotech experience in the fields of Computational Chemistry/Chemoinformatics, Medicinal Chemistry, Biochemistry, Cell and in vivo Biology and DMPK and contribute to several anti-cancer drug discovery projects. As a part of collaborative projects you will also interact with leading academic scientists in Toronto Discovery District.

THE RESPONSIBILITIES OF THE ROLE INCLUDE:
• Collaborate effectively with Medicinal Chemists in the Group and contribute to Drug Discovery projects via a wide variety of Molecular Modeling, Chemoinformatics, Ligand- and Structure-Based Analog Design and Data Mining tools;
• Develop new tools to streamline Computational Drug Discovery (Pipeline Pilot, etc.) and apply them to Drug Discovery projects;
• Participate in new target validation by performing virtual screening to identify new hits, hit expansion, assisting chemists in Hit-to-Lead and Lead Optimization;
• Assist biologists in streamlining uploading of newly generated biological data;
• Present results to internal and external audiences and/or international meetings, contribute to manuscripts for peer-reviewed international journals.

QUALIFICATIONS:
• PhD in Computational Chemistry/Chemoinformatics or a related field with solid theoretical and practical knowledge of different two- and three-dimensional methods of Chemoinformatics, ligand- and structure-based Virtual Screening, QSAR and Data Mining;
• Experience in homology modeling, docking and scoring;
• Proficiency in at least one standard scientific package, i.e. Schrodinger Small Molecule Drug Discovery suite, MolSoft ICM, Pipeline Pilot;
• Experience in at least one scripting or programming language, Pipeline Pilot or KNIME;
• Knowledge of relational databases and some synthetic organic and/or medicinal chemistry is a plus;
• Knowledge of cancer genomics & next generation sequencing data analysis is a big asset;
• Highly motivated and self-dedicated scientist, good team player and excellent interpersonal skills;
• Written and spoken fluency in English and excellent communication skills;
• Enthusiasm to work in an interactive, team environment.

What do we have to offer you? A wide variety of exciting challenges in anti-cancer drug discovery and a working environment that will motivate you, and help you move ahead in your personal development and career. During your employment, you will use the state-of-the-art HPC hardware and front-end Computational and Chemoinformatics software suites, as well as gain insight into the many aspects of preclinical research and development of potential anti-cancer drugs.

The position is for 2 years. OICR provides competitive fellowships dependent on experience. Please submit your CV/resume, list of publications and a statement of interest to Dr. Gennady Poda at gennady.poda@oicr.on.ca.

OICR is an innovative cancer research institute located in the MaRS Centre in the Discovery District in downtown Toronto. OICR is addressing significant challenges in cancer research with multi-disciplinary, multi-institutional teams. New discoveries to prevent, detect and treat cancer will be moved from the bench to practical applications in patients. The OICR team is growing quickly. We are innovative, dedicated professionals who bring expertise to each of our roles. We are looking for individuals interested in being part of a culture of excellence that will result in Ontario being recognized internationally as a leading jurisdiction for cancer research.

Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Research, Innovation and Science.

For more information about OICR, please visit the website at www.oicr.on.ca.

CLOSING DATE: Until filled

OICR is an inclusive employer dedicated to building a diverse workforce. We encourage applications from all qualified candidates and will accommodate applicants’ needs throughout all stages of the recruitment and selection process. Please advise the Recruiter to ensure your accessibility needs are accommodated throughout this process. Information received relating to accommodation will be addressed confidentially.

The Ontario Institute for Cancer Research thanks all applicants. However, only those under consideration will be contacted.

Resume Format: If you elect to apply, you will need a text or HTML version of your resume so that you can cut and paste it into the application box provided. Before you submit the completed application, you will be asked to attach one or two files to your application. Please attach your resume as a .doc file.