Position: Diagnostic Bioinformatician
Site: MaRS Centre, Toronto
Department: Diagnostic Development
Reports To: Director, Diagnostic Development
Salary: Commensurate with level of experience
Hours: 35 hours/week
Status: Full-time, Temporary (one year)
Are you a bioinformatics guru? OICR’s Diagnostic Development Program is looking for a mid-level Bioinformatician to develop biomarker signatures that can be applied to the new paradigm of precision medicine. You will join a team of geneticists, biostatisticians and genomicists to develop, validate and implement modern diagnostic methods for use in pathology labs and services. Our team includes internationally-recognized experts in biomarker discovery and validation, and actively works with diagnostics industry and biotech companies. Our current work includes the use of next generation sequencing to discover biomarkers that stratify risk in breast cancer and prostate cancer, and the development of the methods needed to translate those biomarkers into the clinical laboratory. Working in our group, you will have the opportunity to work with large datasets from clinical trials and to address problems that have direct impact on clinical needs and patient care.
• Preprocessing, processing and interpreting large next generation sequencing data sets to quantify gene expression, copy number aberrations and simple somatic mutations;
• Mining data sets for biomarkers that stratify patients according to their risk of disease progression and/or predict patient response to specific therapies;
• Exploring external biological databases, suggesting integration approaches and building prototypes to evaluate and fine-tune integration plan;Developing tools for data quality control, data validation and reporting;
• Interacting with the Director to design and develop bioinformatics and statistical algorithm approaches for clinical diagnostics. The incumbent will be co-mentored by a Bioinformatics PI;
• Liaising with other OICR experts in next generation sequencing, bioinformatics, and biostatistics to validate approaches;
• Preparing documentation for data specifications and analysis workflows;
• Participating in publications, grant writing and program funding review.
• PhD or post-doctorate in computational biology/bioinformatics or related field with 3-5 years professional experience;
• Knowledge of genomics, molecular and/or cancer biology;
• Experience with the analysis of next generation sequencing data;
• Experience with bioinformatics resources, databases, tools and common standard formats used in NGS;
• Strong scripting skills (R/python/perl), expertise in a statistical environment (matlab or R), and comfort working in Linux environment;
• Experience in biostatistics, particularly survival or Bayesian techniques;
• Excellent writing and communication skills;
• Experience with meeting publication, grant and experimental deadlines;
• Ability to work independently and mentored by our Informatics team.
• Experience with and in-depth knowledge of data modeling;
• Experience in machine-learning methods;
• Experience with clinical trials an asset;
• Previous experience in developing algorithms that have been implemented in a clinical diagnostic test highly preferred;
• Post-graduate research work in network modelling of cancer cell signaling networks, cancer heterogeneity and transcriptional regulatory networks;
• Previous experience working with Nanostring data is a plus;
• Data-visualization capabilities for large datasets.
OICR is an innovative cancer research institute located in the MaRS Centre in the Discovery District in downtown Toronto. OICR is addressing significant challenges in cancer research with multi-disciplinary, multi-institutional teams. New discoveries to prevent, detect and treat cancer will be moved from the bench to practical applications in patients. The OICR team is growing quickly. We are innovative, dedicated professionals who bring expertise to each of our roles. We are looking for individuals interested in being part of a culture of excellence that will result in Ontario being recognized internationally as a leading jurisdiction for cancer research.
Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Research, Innovation and Science.
For more information about OICR, please visit the website at www.oicr.on.ca.
CLOSING DATE: Until Filled
OICR is an inclusive employer dedicated to building a diverse workforce. We encourage applications from all qualified candidates and will accommodate applicants’ needs throughout all stages of the recruitment and selection process. Please advise the Recruiter to ensure your accessibility needs are accommodated throughout this process. Information received relating to accommodation will be addressed confidentially.
The Ontario Institute for Cancer Research thanks all applicants. However, only those under consideration will be contacted.
Resume Format: If you elect to apply, you will need a text or HTML version of your resume so that you can cut and paste it into the application box provided. Before you submit the completed application, you will be asked to attach one or two files to your application. Please attach your resume as a .doc file.