Position: Postdoctoral Fellow
Site: MaRS Centre, Toronto
Department: Diagnostic Development
Reports To: Principal Research Scientist
Salary: Commensurate with level of experience
Hours: 35 hours/week
Status: Full-time, Temporary (2 year contract)
The Ontario Institute for Cancer Research (OICR) is seeking a highly motivated and qualified postdoctoral fellow who possesses relevant training in proteomics or molecular biology and interested in cancer biology to join the Diagnostic Development program. This is a 2-year contract with the potential to extend.
The successful candidate will join a highly dynamic and translational research program in biomarker discovery in various cancer types. The program aims to develop personalized medicine approaches that maximize the chance of positive outcomes for those diagnosed with cancer. The project will use clinical cohorts to examine the predictive and translational value of the tumour and the immune microenvironment on treatment. The aim of the project is to develop and perform spatial transcriptomic and proteomic profiling to identify and characterise targets and associated biomarkers for cancer treatment.
The MaRS Centre has a mandatory COVID-19 vaccination policy in place that requires proof of full COVID-19 vaccination or proof of a medical exemption issued pursuant to the Government of Ontario guidelines. Accordingly, as a condition of employment, new employees who are required to work on-site are required to be fully vaccinated for COVID-19 subject to the duty to accommodate on the basis of protected grounds pursuant to the Ontario Human Rights Code.
Fully vaccinated is defined as having received all of the required doses of a Health Canada approved vaccine and having received the final dose at least 14 days before your employment start date.
As described above, the requirement to be fully vaccinated is subject to the Ontario Human Rights Code. If the candidate is unable to receive the COVID-19 vaccine for a reason protected by the Code, requests for accommodation from the vaccine policy will be assessed on a case-by-case basis.
Learn more about working at OICR here
The project will focus on spatial transcriptomics, proteomics and imaging techniques using state-of-the-art techniques for biomarker detection in archival clinical samples. The successful candidate will use cutting-edge molecular pathology techniques such multiplexed immunohistochemistry (Nanostring GeoMx DSP) advances in image analysis and machine learning and applying molecular techniques such as genomic and transcriptomic profiling in formalin-fixed, paraffin-embedded tissue. They will have demonstrated a solid understanding of biology and genomics, programming skills, and experience with high-throughput molecular sequencing technologies.
- Molecular biology approaches working with DNA, RNA, and proteins;
- Compiles experimental and analytical data, preparing presentations and publications;
- Perform multiplex in-situ based proteomics analysis in archival tissue;
- Apply bioinformatic tools for integrating results from different biological resources; and
- Authoring and co-authoring manuscripts submitted to high impact journals
- PhD in molecular biology or related field within the past four years;
- First author publications in peer reviewed journals;
- Experience in the integration of molecular profiling data including transcriptomic, proteomic, and genomic datasets, into a broader understanding of cell regulation within the tumor and interactions between the tumor, the tumor microenvironment and immune system
- Experience in statistics and bioinformatic data analysis using scripts and code (SPSS, R, etc) an asset;
- Demonstrated ability to work independently and as part of a team;
- Attention to detail and strong organizational skills; and
- Excellent verbal and written communication skills.
OICR is a collaborative, not-for-profit research institute accelerating the development of new cancer research discoveries for patients around the world while maximizing the economic benefit of this research for the people of Ontario. We are dedicated professionals who bring expertise to each of our roles. We are looking for individuals who share our values of excellence, innovation, collaboration, impact, responsibility and community.
Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Colleges and Universities.
For more information about OICR, please visit the website at www.oicr.on.ca.
CLOSING DATE: Until Filled
OICR is an inclusive employer dedicated to building a diverse workforce. We encourage applications from all qualified candidates and will accommodate applicants’ needs throughout all stages of the recruitment and selection process. Please advise the Recruiter to ensure your accessibility needs are accommodated throughout this process. Information received relating to accommodation will be addressed confidentially.
The Ontario Institute for Cancer Research thanks all applicants. However, only those under consideration will be contacted.
Resume Format: If you elect to apply, you will need a text or HTML version of your resume so that you can cut and paste it into the application box provided. Before you submit the completed application, you will be asked to attach one or two files to your application. Please attach your resume as a .pdf or .doc file.