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Current Opportunities

Research Associate, Analytical Chemistry - Toronto, Ontario

Position: Research Associate, Analytical Chemistry
Site: MaRS Centre, Toronto
Department: Drug Discovery Program
Reports To: Principal Research Scientist & Group Leader
Salary: Commensurate with level of experience
Hours: 35 hours/week
Status: Full-time, Permanent

The Ontario Institute for Cancer Research (OICR) Drug Discovery Group is seeking a Research Associate (Analytical Chemistry) to develop and apply state-of-the-art analytical methods (LC-MS, HPLC etc.) to support drug discovery efforts including ADME.

The OICR Drug Discovery Program is one of the largest programs of its kind in Canada. Our mission is to help efficiently translate discoveries made in Ontario’s labs into novel oncology therapies. The team is comprised of more than 25 researchers whose collective expertise spans the entire drug discovery process from target identification and validation to clinical candidate selection. The group has extensive drug discovery experience within pharma and biotech environments and combines the disciplines of biology, ADME/PK, analytical, medicinal, and computational chemistry expertise along with state-of-the-art infrastructure necessary to successfully conduct drug discovery projects.

The MaRS Centre has a mandatory COVID-19 vaccination policy in place that requires proof of full COVID-19 vaccination or proof of a medical exemption issued pursuant to the Government of Ontario guidelines.  Accordingly, as a condition of employment, new employees who are required to work on-site are required to be fully vaccinated for COVID-19 subject to the duty to accommodate on the basis of protected grounds pursuant to the Ontario Human Rights Code.  

Fully vaccinated is defined as having received all of the required doses of a Health Canada approved vaccine and having received the final dose at least 14 days before your employment start date. 

As described above, the requirement to be fully vaccinated is subject to the Ontario Human Rights Code. If the candidate is unable to receive the COVID-19 vaccine for a reason protected by the Code, requests for accommodation from the vaccine policy will be assessed on a case-by-case basis.  

Learn more about working at OICR here.


  • Prepare samples from biological and non-biological matrices with or without automation;
  • Perform qualitative and quantitative analysis using various LC-MS methods;
  • Maintain analytical instruments;
  • Perform routine in vitro ADME (absorption, distribution, metabolism, and excretion) assays to guide chemistry structure-activity relationships (SAR);
  • Analyze in vitro samples utilizing LC-MS/MS;
  • Maintain records of experimental procedures and data;
  • Assist in compound management, including compound dispensing, storage, robotics, registration, and database management as needed;
  • Liaise effectively with multi-disciplinary team members (medicinal chemistry and biology);
  • Work effectively under pressure and tight timelines;
  • Adhere to all OICR safety guidelines and policies, strongly advocate safety to others.


  • BSc in Chemistry with 2-4 years of experience or MSc in Analytical Chemistry or related field with 1-2 years of experience in small molecule drug discovery analytical support;
  • Experience with HPLC, LC-MS, LC-MS/MS for small molecule applications;
  • Knowledge of general organic chemistry;
  • Basic knowledge of ADME is desirable;
  • Excellent written and oral communication skills;
  • Strong team player and excellent interpersonal skills;
  • Demonstrated ability to work independently and as part of a team;
  • Highly motivated self-starter that enjoys an element of ambiguity and capable of adapting to a changing environment.

OICR is a collaborative, not-for-profit research institute accelerating the development of new cancer research discoveries for patients around the world while maximizing the economic benefit of this research for the people of Ontario. We are dedicated professionals who bring expertise to each of our roles. We are looking for individuals who share our values of excellence, innovation, collaboration, impact, responsibility and community.

Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Colleges and Universities.

For more information about OICR, please visit the website at www.oicr.on.ca.

CLOSING DATE: Until Filled.

OICR is committed to fostering a climate of equity, diversity, inclusion, and accessibility. This commitment is central to, and mutually supportive of, our research excellence mandate. We welcome and respect the diversity of all members of our community and we support an inclusive culture for all. We welcome all applicants, and encourage applications from racialized persons, Indigenous Peoples, women, persons with disabilities, LGBTQ2S persons, and others who may contribute to furthering a diversity of ideas within our community. OICR is committed to fair assessment of a candidate’s abilities, and consideration for diversity of thought, method, and experience. Providing an accessible workplace and recruitment process is important to us, as described in our Accessibility Plan (https://oicr.on.ca/accessibility/) Should you require accommodation during any stage in the recruitment process, please complete the form at the bottom of page https://oicr.on.ca/careers/. Information received related to accommodation will be handled confidentially.  

The Ontario Institute for Cancer Research thanks all applicants. However, only those under consideration will be contacted.

Resume Format: If you elect to apply, you will need a text or HTML version of your resume so that you can cut and paste it into the application box provided. Before you submit the completed application, you will be asked to attach one or two files to your application. Please attach your resume as a .pdf or .doc file.