Careers at UHN

Job Description



Scientific Associate I - Toronto, Ontario

Job Posting #887817

Position: Scientific Associate I
Site: Krembil Research Institute
Department: Centre for Medicinal Chemistry and Drug Discovery
Reports to: Principal Investigator
Salary Range: $65,091 to $81,354 per annum commensurate with experience and consistent with the UHN Compensation Policy
Hours: 37.5 hours per week
Status: Temporary Full-time (1 year)

University Health Network (UHN) is looking for an experienced professional to fill the key role of Scientific Associate I in our Centre for Medicinal Chemistry and Drug Discovery.

Transforming lives and communities through excellence in care, discovery and learning.

The University Health Network, where “above all else the needs of patients come first”, encompasses Toronto Rehabilitation Institute, Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre and the Michener Institute of Education at UHN. The breadth of research, the complexity of the cases treated, and the magnitude of its educational enterprise has made UHN a national and international resource for patient care, research and education. With a long tradition of groundbreaking firsts and a purpose of “Transforming lives and communities through excellence in care, discovery and learning”, the University Health Network (UHN), Canada’s largest research teaching hospital, brings together over 16,000 employees, more than 1,600 physicians, 8,000+ students, and many volunteers. UHN is a caring, creative place where amazing people are amazing the world.

University Health Network (UHN) is a research hospital affiliated with the University of Toronto and a member of the Toronto Academic Health Science Network. The scope of research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. Research across UHN's seven research institutes spans the full spectrum of diseases and disciplines, including cancer, cardiovascular sciences, transplantation, neural and sensory sciences, musculoskeletal health, rehabilitation sciences, and community and population health. Find out about our purpose, values and principles here.

We are currently looking for outstanding candidates to join our growing team at the Centre for Medicinal Chemistry and Drug Discovery within the Krembil Research Institute, University Health Network. You will be part of an exciting multi-disciplinary team tasked with translating new biological discoveries into druggable targets. The successful candidate will join one of the Krembil’s vibrant multi-disciplinary academic drug discovery groups consisting of over 50 biochemists, molecular biologists, behavioral neuroscientists, computational, analytical and medicinal chemists.

In this role, you’ll work closely with academic researchers to establish a strategy for evaluating and validating new drug targets from basic research. You will work with a multi-disciplinary team to create a pre-clinical strategy and develop small molecule probes for proof of concept and validation of novel therapeutic targets. You’ll be responsible for generating synthetic routes to small molecule candidates, and up to 25% of your time may be spent doing synthesis in the lab.

You should apply if you love to:
     Immerse yourself in new projects and develop research proposals
     Ask the key questions to evaluate possible targets for drug discovery
     Follow a drug discovery project from early-stage target validation to lead optimization
     Design and synthesize chemical probes or drug candidates
     Build relationships and discuss highly technical concepts with academic collaborators and investors
     Be the chemistry expert on a multi-disciplinary team

Responsibilities of the Scientific Associate I include: conducting outreach with new academic collaborators and build existing relationship with PIs; evaluating new research programs to determine how they could be translated to druggable targets; developing a strategy to design, synthesize, and test small molecule probes for target validation and proof of concept studies; identifying and writing translational grants to fund drug discovery programs; communicate results and proposals orally and in writing with research groups, investors and foundations; performing additional duties as required.

Qualifications
• At minimum, a PhD in synthetic organic, medicinal chemistry or closely related field
• Up to 1 year postdoctoral fellowship and/or experience required; within the life science/biotechnology sector preferred
• Strong knowledge of concepts in biochemistry, pharmacology and drug discovery
• Effective team player with strong, collaborative trouble-shooting skills
• Experience working in multi-disciplinary teams is an asset
• Solid documentation skills and organizational ability
• Excellent problem recognition and problem-solving skills
• Proficient verbal and written communication skills
• Ability to work independently and accurately under strict timelines
• Abide by applicable institutional and departmental policies, procedures, guidelines, protocols, and practices

Vaccines (COVID and others) are a requirement of the job unless you have an exemption on a medical ground pursuant to the Ontario Human Rights Code.

If you are interested in making your contribution at UHN, please apply on-line. You will be asked to copy and paste as well as attach your resume and covering letter. You will also be required to complete some initial screening questions.

Posted Date: November 4, 2021                          Closing Date: December 9, 2021

For current UHN employees, only those who have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN's attendance management program, and possess all the required experience and qualifications should apply.

UHN thanks all applicants, however, only those selected for an interview will be contacted.

UHN is a respectful, caring, and inclusive workplace. We are committed to championing accessibility, diversity and equal opportunity and welcomes all applicants including but not limited to: all religions and ethnicities, LGBTQ2s+, BIPOC, persons with disabilities and all others who may contribute to the further diversification of ideas. Requests for accommodation can be made at any stage of the recruitment process providing the applicant has met the Bona-fide requirements for the open position. Applicants need to make their requirements known when contacted.



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